The average brain volume of humans increases with increasing myelination of the neurons which results in more stable and efficient neurological function. From this perspective, the human brain does not reach full maturity until age 40-50, which is when the average population brain volume reaches its maximum. After age 50, the population average brain volume begins to decrease as subsets of the population begin to experience neurodegeneration. Some neurodegeneration is mostly gray matter related (neuronal) and some neurodegeneration is mostly white matter related (glial). Neither type is exclusive. White matter loss is associated with gray matter loss and vice versa. By age 90, the average human brain has shrunk by 20%.
To access the FREE seminars with full presentations and videos please visit Dr. Goodenowe’s resource site here. This is the article for Lecture 8 – The Biochemistry of Brain Volume, of Breaking Alzheimer’s – The Definitive Lecture Series.
Age-associated gray matter and white matter loss are mostly global phenomena. Region-specific brain volume loss is more associated with specific clinical outcomes such as hippocampal volume and cognition. However, these associations are rarely yes or no events. They almost always occur as rates of decline greater than the generalized average age-associated rate of decline.
Total brain volume is an independent risk factor for all-cause mortality. Brain volume stability is associated with cognitive stability. Brain volume is a big deal.
So, what is the biochemistry of brain volume maintenance and brain volume decline? Is brain volume decline a one-way street or can brain volume be restored? Join Dr. Goodenowe for Lecture 8 – The Biochemistry of Brain Volume and find the answers to these questions and many more. In Lecture 8 – The Biochemistry of Brain Volume, Dr. Goodenowe explains the relevant research and literature relating to the biochemistry of brain volume. The lectures integrate Dr. Goodenowe’s own research and over 50 years of research from leading researchers from around the world.