Part I – Beware of what appears to be logically obvious A lot of things in our world appear obvious only to be proven wrong by experimentation. For most of us, the world is flat – it looks flat, it feels flat. A flat earth is the most obvious hypothesis based upon our everyday experience. …
I am the first and only scientist to solve the biochemical mechanism and cause of reduced cognition – a deficiency of plasmalogens in the synaptic membrane of cholinergic neurons leads to a reduced uptake of choline following a neuron firing event. Reduced synaptic choline uptake results in excessive de novo intracellular choline synthesis via methyltransferase activity (which causes elevated homocysteine) and membrane catabolism (which causes cell shrinkage) to sustain sufficient acetylcholine levels for nerve transmission. Using data from multiple independent international …
The first step in the Breaking Alzheimer’s journey is to understand the differences between health and disease, life and death, and average lifespan versus maximum lifespan. Loss of function leads to disease and then to death. The average time to death from a diagnosis of Alzheimer’s is about five years. So, let’s start by understanding …
About one in four persons have a genetic predisposition for Alzheimer’s disease and dementia caused by having one or two copies of the ɛ4 allele of the gene APOE. Over half of the persons with Alzheimer’s have this gene allele. Population-based genotyping for this genetic risk is not recommended because there are no widely accepted protocols …
Lecture 7 – APOE: Breaking Alzheimer’s – The Definitive Lecture Series Read More »
Throughout most of human history, senile dementia (which occurs after age 65) has been considered a natural part of the aging process. It was not until the 20th century that scientists began to investigate and hypothesize regarding the cause of senile dementia more seriously. At the turn of the century, Dr. Alois Alzheimer was the first …
Lecture 1 – Introduction: Breaking Alzheimer’s – The Definitive Lecture Series Read More »
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