Immortal Neurology: Building & Maintaining an Immortal Brain

Dr. Dayan Goodenowe’s insightful presentation from RAADFest 2024 is now available for viewing. In this talk, Dr. Goodenowe explores the concept of immortality from a scientific and biochemical standpoint, redefining immortality not as living forever but as the body’s ability to adapt and maintain its health over time. By understanding the causes of death and the loss of adaptability, he offers a new perspective on extending our lives by fostering the right environmental conditions.

Key points from the presentation include:

• The environment is critical to health, influencing the body’s ability to repair and adapt to changes.
• Immortality is framed as the body’s capacity to maintain balance and avoid maladaptation rather than an unattainable goal.
• Aging and disease are tied to a loss of adaptability, often caused by an imbalance in biochemical processes.
• Practical steps for longevity include:
  • Maintaining a supportive environment that provides essential resources.
  • Addressing biochemical imbalances to prevent disease and support health.
  • Fostering personal habits, such as proper nutrition and exercise, enables the body to repair itself naturally.

Referenced in the presentation:

Patents

• Method for the treatment of senile dementia of the Alzheimer’s type

• Plasmalogen compounds, pharmaceutical compositions containing the same and methods for treating diseases of the aging

Book

• Breaking Alzheimer's: A 15 Year Crusade to Expose the Cause and Deliver the Cure

Articles

• Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease

• Targeted Plasmalogen Supplementation: Effects on Blood Plasmalogens, Oxidative Stress Biomarkers, Cognition, and Mobility in Cognitively Impaired Persons

• Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum

• Characterization of Brain Volume Changes in Aging Individuals With Normal Cognition Using Serial Magnetic Resonance Imaging

• Association of Age and Structural Brain Changes With Functional Connectivity and Executive Function in a Middle-Aged to Older Population-Based Cohort

• Association of Serum-based Plasmalogens with Neuroimaging and Genetic Variation in Alzheimer’s Disease

• Signatures of white-matter microstructure degradation during aging and its association with cognitive status

• Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

• Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation

• Betz cells of the primary motor cortex

• Locus Coeruleus Stimulation Recruits a Broad Cortical Neuronal Network and Increases Cortical Perfusion