Dr. Dayan Goodenowe at the Community Health Summit in Moose Jaw
Dr. Dayan Goodenowe’s presentation explores early brain development, with a specific focus on the role of myelination and its disruption in neurodevelopmental disorders like autism. He discusses that myelination is the biological process of learning, and its integrity is paramount for cognitive and neuromuscular function.
Some of the main points discussed are:
- The fundamental role of myelination in brain development
- Plasmalogens as the critical building block for myelin
- The newborn plasmalogen deficit and the role of breast milk
- Impaired myelination as the core issue in autism
- Case studies show the potential of plasmalogen precursor supplementation
References from Dr. Goodenowe’s presentation:
- The early development of brain white matter: A review of imaging studies in fetuses, newborns and infants Dubois, J. et al. Neuroscience, Volume 276, 48 – 71
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2008). Metabolism and Functions of Bioactive Ether Lipids in the Brain. Springer Science + Business Media.
Andre Teigler, Dorde Komljenovic, Andreas Draguhn, Karin Gorgas, Wilhelm W. Just, Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum, Human Molecular Genetics, Volume 18, Issue 11, 1 June 2009, Pages 1897–1908.
- Manuela Martínez, Angel Ballabriga, A chemical study on the development of the human forebrain and cerebellum during the brain ‘growth spurt’ period. I. Gangliosides and plasmalogens, Brain Research, Volume 159, Issue 2, 1978, Pages 351-362,
- Labadaridis I, Moraitou M, Theodoraki M, Triantafyllidis G, Sarafidou J, Michelakakis H. Plasmalogen levels in full-term neonates.
Bo Hallgren, Sam Larsson. The glyceryl ethers in man and cow.
- Sean C.L. Deoni, Douglas C. Dean, Irene Piryatinsky, Jonathan O’Muircheartaigh, Nicole Waskiewicz, Katie Lehman, Michelle Han, Holly Dirks, Breastfeeding and early white matter development: A cross-sectional study
Deoni SC, O’Muircheartaigh J, Elison JT, Walker L, Doernberg E, Waskiewicz N, Dirks H, Piryatinsky I, Dean DC 3rd, Jumbe NL. White matter maturation profiles through early childhood predict general cognitive ability.
Patent – Method for the treatment of senile dementia of the Alzheimer’s type
- Rishikesh Mankidy, Pearson WK Ahiahonu, Hong Ma, Dushmanthi Jayasinghe, Shawn A Ritchie, Mohamed A Khan, Khine K Su-Myat, Paul L Wood and Dayan B Goodenowe. Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study.
- Patent – Methods for the diagnosis, risk assessment, and monitoring of Autism Spectrum Disorders.
- Pastural E, Ritchie S, Lu Y, Jin W, Kavianpour A, Khine Su-Myat K, Heath D, Wood PL, Fisk M, Goodenowe DB. Novel plasma phospholipid biomarkers of autism: mitochondrial dysfunction as a putative causative mechanism.
- Dayan Goodenowe, Elodie Pastural. The Biochemical Basis of Autistic Behavior and Pathology
- Baird G, Cass H, Slonims V. Diagnosis of autism.
- Aoki Y, Abe O, Nippashi Y, Yamasue H. Comparison of white matter integrity between autism spectrum disorder subjects and typically developing individuals: a meta-analysis of diffusion tensor imaging tractography studies.
- Al-Farsi YM, Al-Sharbati MM, Waly MI, Al-Farsi OA, Al-Shafaee MA, Al-Khaduri MM, Trivedi MS, Deth RC. Effect of suboptimal breast-feeding on occurrence of autism: a case-control study.
- Huang S, Wang X, Sun T, Yu H, Liao Y, Cao M, Cai L, Li X, Lin L, Su X, Jing J. Association of Breastfeeding for the First Six Months of Life and Autism Spectrum Disorders: A National Multi-Center Study in China.
- Nevison C, Parker W. California Autism Prevalence by County and Race/Ethnicity: Declining Trends Among Wealthy Whites.
- Yoo SM, Kim KN, Kang S, Kim HJ, Yun J, Lee JY. Prevalence and Premature Mortality Statistics of Autism Spectrum Disorder Among Children in Korea: A Nationwide Population-Based Birth Cohort Study.
- Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism.
- Vega-Riquer JM, Mendez-Victoriano G, Morales-Luckie RA, Gonzalez-Perez O. Five Decades of Cuprizone, an Updated Model to Replicate Demyelinating Diseases.
- Lee DK, Lee H, Ryu V, Kim SW, Ryu S. Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder.
- Ogawa S, Hattori K, Ota M, Hidese S, Miyakawa T, Matsumura R, Yokota Y, Ishida I, Matsuo J, Yoshida S, Yamazaki Y, Goodenowe D, Kunugi H. Altered ethanolamine plasmalogen and phosphatidylethanolamine levels in blood plasma of patients with bipolar disorder.