At the 25th Annual Meeting of the Japanese Society of Anti-Aging Medicine in Osaka, Japan, Dr. Dayan Goodenowe and Dr. Yasuyo Yamazaki presented new findings on the potential for reversing brain aging and vision loss using plasmalogen precursor supplementation.
Their talk, “Reversal of Brain Aging and Vision Loss using Plasmalogen Precursor Supplementation: An Advanced Longitudinal MRI Analysis,” focused on two longitudinal case studies that evaluated brain structure and function changes using advanced MRI technologies.
Understanding Plasmalogens
Plasmalogens are key structural components of brain membranes and play a critical role in synaptic function and myelin integrity. Declines in plasmalogen content are associated with aging and neurological diseases. Previous studies have shown that plasmalogen precursors can increase blood plasmalogen levels and cognitive function, and reduce brain plasmalogen loss in animal models of multiple sclerosis and Parkinson’s disease.
Case 1
-
Participant: 53-year-old female with multiple sclerosis
-
Condition: Legally blind in the right eye for 30 years
-
Results: After 1 year of plasmalogen precursor supplementation, vision in the right eye and leg mobility were restored.
-
MRI Findings: Restoration of structural and functional connectivity of the occipital cortex, motor cortical thickness, and connectivity to the thalamus and brainstem.
Case 2
-
Participant: 55-year-old male with normal health
-
Condition: MRI showed cortical thinning, gray matter loss, and white matter microstructure degradation consistent with age.
-
Results: After 30 months of plasmalogen precursor supplementation, cortical thickness and gray matter increased, and white matter microstructure was restored.
-
Conclusion: Brain changes were consistent with an approximate 20-year age reversal. Improvements in vision, cognition, and mobility were reported.
Advanced longitudinal MRI was used to measure brain structure and connectivity. Serial blood samples were analyzed using mass spectrometry to monitor changes in plasmalogen levels and oxidative stress biomarkers.
The findings suggest that plasmalogen precursors may restore brain structure and function. Larger clinical trials are warranted.
Stay tuned for the session recording!
Disclaimer: Content is provided for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. Any mentioned products and services are intended for research, educational, and informational use only and are not intended to diagnose or treat any disease.